Histamine Intolerance and the Connection to Perimenopause


Histamine Intolerance

As women journey through perimenopause, they may encounter a myriad of physical and hormonal changes. One lesser-known challenge that can emerge during this time is histamine intolerance. While histamine intolerance is not exclusive to perimenopause, its prevalence and impact seem to be heightened during this transition. Let’s dive into what histamine intolerance is, how it relates to perimenopause, and strategies to manage this often overlooked condition.

Understanding Histamine Intolerance

Histamine is a naturally occurring compound in our bodies that plays a vital role in various bodily functions, including regulating stomach acid, immune responses, and neurotransmitter release. However, for some women, the balance between histamine production and the breakdown of it is disrupted, leading to histamine intolerance.

Histamine intolerance occurs when histamine builds up in the bloodstream. This can happen due to a deficiency of the enzyme diamine oxidase (DAO) or histamine N-methyltransferase (HNMT), which are responsible for breaking down histamine in the gut and other tissues. As a result, excess histamine accumulates in the body, triggering a range of uncomfortable symptoms.

Histamine Intolerance and Perimenopause: Unraveling the Connection

One theory behind the increased susceptibility to histamine intolerance during perimenopause is the impact of hormonal fluctuations on DAO and HNMT enzyme activity. Estrogen, for instance, can enhance histamine release, making the body more prone to histamine accumulation. Additionally, progesterone, which helps stabilize mast cells (cells responsible for histamine release), decreases as menopause approaches, potentially exacerbating histamine-related symptoms.

Common Symptoms of Histamine Intolerance

Histamine intolerance can manifest through various symptoms that often mimic other conditions, making it challenging to diagnose. Some common symptoms include:

  1. Digestive issues: Abdominal pain, bloating, diarrhea, and constipation may occur due to histamine’s influence on stomach acid production and gut motility.
  2. Skin reactions: Itchy skin, hives, redness, and flushing can result from histamine’s impact on blood vessels and immune responses.
  3. Respiratory problems: Histamine can lead to nasal congestion, sneezing, wheezing, and other respiratory symptoms in sensitive individuals.
  4. Headaches and migraines: Excess histamine can trigger headaches, especially migraines, by affecting blood vessel dilation and neurotransmitter release.
  5. Fatigue and brain fog: Histamine’s interaction with neurotransmitters can contribute to feelings of fatigue, difficulty concentrating, and mental fogginess.

Click here for a more thorough list of symptoms (there are 47!)

Managing Histamine Intolerance During Perimenopause

While histamine intolerance can be challenging, managing it during perimenopause is possible with a combination of lifestyle changes and targeted interventions:

  1. Dietary adjustments

     Adopting a low-histamine diet involves avoiding or limiting foods that are high in histamine or trigger histamine release. These may include aged cheeses, processed meats, fermented foods, and alcohol.

  2. Supplements

    DAO enzyme supplements are available over the counter and can help enhance histamine breakdown in the gut. However, their effectiveness can vary from person to person.

  3. Probiotics

    Certain strains of probiotics can assist in maintaining a healthy gut environment, which may indirectly support histamine regulation.

  4. Stress management

    Stress can exacerbate histamine intolerance symptoms. Incorporating relaxation techniques such as deep breathing, meditation, and yoga can help alleviate stress and its impact.

  5. Consultation with healthcare professionals

    If you suspect histamine intolerance, consult with a healthcare professional to rule out other conditions and develop a personalized management plan.

Perimenopause is a transformative phase in a woman’s life, characterized by hormonal fluctuations that can influence various bodily systems. Histamine intolerance, though often overlooked, can emerge or intensify during this time due to hormonal changes affecting enzyme activity and histamine regulation. Recognizing the connection between perimenopause and histamine intolerance empowers women to seek appropriate management strategies, such as dietary modifications, supplements, and stress reduction.

Click the link below to access a full list of products for histamine intolerance I trust from Fullscript. 

Dr. Anna Garrett is a menopause expert and Doctor of Pharmacy. She helps women who are struggling with symptoms of perimenopause and menopause find natural hormone-balancing solutions so they can rock their mojo through midlife and beyond. Dr. Anna is the author of Perimenopause: The Savvy Sister’s Guide to Hormone Harmony. Order your copy at www.perimenopausebook.com.

Dr. Anna is available for 1-1 consultation. Find out more at www.drannagarrett.com/lets-talk.

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