The Power of Progesterone from A to Z
28 Nov 2018

The Power of Progesterone from A to Z

Progesterone is a sex hormone that is typically thought of when it comes to maintaining pregnancy or for protection against uterine cancer when supplemental estrogen is used for hormone replacement.  At least that’s how most conventional physicians file it in their mental database.

But here’s the truth of it. What you may not realize is that it has benefits FAR beyond uterine protection and pregnancy maintenance. I get loads of questions about progesterone because there is so much confusion floating around. There are a lot of myths and misunderstandings about progesterone, so I put together this A to Z list that’s all about the power of this hormone.

A: Allopregnanolone is a metabolite that is created when progesterone is taken orally. Of the three that are produced, this is the one that contributes the most to drowsiness. Oral progesterone is most effective for sleep (vs. cream).

B: Progesterone has been shown in clinical studies to have a protective effect against breast cancer.

C: Progesterone is your calming hormone. In perimenopause, progesterone drops and this contributes to mood swings and anxiety. Supplementing with progesterone can bring back the calm!

D: Progesterone comes in a number of dosage forms. These include capsules, creams, troches, and oil. Cream and oil are available over-the-counter. Capsules and troches require a prescription.

E: Progesterone increases energy by stimulating the thyroid and increasing metabolism.

F: Progesterone is your “feel-good” hormone. When it drops so does your mood and energy.

G: Natural progesterone can be beneficial with regard to the gut’s healing process. It has anti-inflammatory and anti-stress properties and has been shown to work as a natural relaxant in the GI tract.

H: Many doctors still believe that progesterone isn’t necessary after a hysterectomy. That’s old-school thinking. Progesterone isn’t just about uterine protection, it’s good for a host of other organ systems (as you can see from this list).

I: IUDs don’t contain PROGESTERONE. They contain synthetic PROGESTIN. These products (Mirena and Skylar) do not provide the positive benefits of progesterone and have been associated with a small increase in breast cancer risk.

J: Studies have shown that progesterone replacement has significantly improved pain and other symptoms in patients with bone and joint conditions.

K: Progesterone keeps estrogen under control. Estrogen stimulates growth and progesterone keeps that growth from getting out of control. When ovulation is irregular, estrogen runs the show which results in symptoms of overload (breast tenderness, heavy periods, etc).

L: Progesterone lightens bleeding and can be used to stop flooding periods.

M: The estrogen dominance that is so common during perimenopause can trigger a migraine, due to estrogen’s excitatory nature. Often, 2% bioidentical progesterone cream is all you need to relieve premenstrual or menopausal migraines.

N: Nerve health. Progesterone improves the integrity and function of cell membranes. In the brain, progesterone receptors help protect nerve tissue.

O: Progesterone is made when you ovulate. No ovulation=very low progesterone and increased symptoms of estrogen dominance.

P: PROGESTIN is not progesterone. It is a fake progesterone and is synthetic. It does not have the positive benefits of progesterone. It WILL slow down heavy bleeding but will not do all of the other awesome things on this list!

Q: Because it gets into the brain, progesterone helps quiet anxiety.

R: Low progesterone can cause a rapid heartbeat. Any heart rhythm abnormalities should be checked out to make sure it’s not something serious, but supplementing progesterone may kick palpitations to the curb.

S: Progesterone has few side effects and is very safe. The most common side effect is drowsiness and occasionally, depression.

T: Progesterone is very commonly used topically (on the skin) as a route of administration.

U: Utrogestan. This is the brand name of progesterone in the UK.

V: Vaginal dosing of progesterone is another alternative to oral or topical forms. It’s very well absorbed using this route.

W: Because progesterone raises body temperature slightly, it can be helpful for weight loss.

X: Xenoestrogens. These are fake estrogens found in the environment (think plastics and pesticides). Progesterone can help counteract the effects of these compounds.

Y: Yams (as in wild). Diosgenin is a substance found in wild yams and it is the starting compound for USP progesterone. The conversion to progesterone cannot be done by the body, so it’s done is a lab. The resulting hormone is bioidentical, which means it is the exact chemical structure as progesterone from the ovaries.

Z: ZZZs! Insomnia is a very common sign of low progesterone. Supplementing with oral progesterone capsules is very helpful for many women who struggle with lack of sleep.


Got more questions about progesterone? Curious about your own levels? Let’s talk!

Dr. Anna Garrett is a menopause expert and Doctor of Pharmacy. She helps women who are struggling with symptoms of perimenopause and menopause find natural hormone balancing solutions so they can rock their mojo through midlife and beyond. Her clients would tell you that her real gift is helping them reclaim parts of themselves they thought were gone forever.

Find out more about working with her at

Dr. Anna Garrett


  1. Extremely helpful! Thanks so much. I csn’t Believe the difference it has made for me. I wish that I had tried it years ago !

  2. I am an breast cancer survivor I believe that being on birth control pills over a period of 19 years was the culprit? My cancer was also estrogen receptive. I was 37 at the time 58 now. What is safe for me to take at this time of my life? I haven’t had a period since June of 98 the chemo through me rite into menopause.

  3. Very cool to be informed, thank you!

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